RAF Typhoon fighter aircraft have operated alongside French warplanes in a coordinated attack on an hidden munitions depot in Syrian territory employed by the IS group, according to the UK's MoD.
The site, located using surveillance, was believed to be containing munitions and bombs, the statement said, and was positioned in mountains just to the north of the ancient city of Palmyra in Syria's central region.
"The RAF jets used precision-guided Paveway IV munitions to target a several access tunnels providing entry to the facility... preliminary assessments are that the target was engaged successfully," the ministry announced.
There was no indication of any harm to civilians in the strike conducted Saturday night and each participating jet made a safe return, the ministry further stated.
The Typhoon FGR4s were assisted by a Voyager aerial refuelling aircraft.
The Islamic State group - referred to as Daesh - enforced jihadist rule over large swathes of both Syria and Iraq until 2019.
"This action underscores British leadership, and commitment to operate in unison with our partners, to stamp out any resurgence of Daesh and their dangerous and violent ideologies in the Middle East," Britain's Defence Chief the Defence Secretary remarked.
British military aircraft have carried out overwatch operations over Syrian airspace to "deter any efforts to regroup" of the group following its military defeat at the battle of Baghuz in 2019, the ministry said.
"I extend gratitude to every member of British forces involved in this operation for their skill and their bravery," Healey added. "They were part of numerous British troops deployed over the holidays. This operation, to remove militants who endanger our security, highlights how British military are always on standby, throughout the year, protecting the UK domestically and powerful internationally."
During December, the United States armed forces executed what it termed a "major assault" targeting IS targets in the country, after an attack resulted in the deaths of two US servicemembers and a civilian interpreter in Palmyra.
The United Nations says Islamic State still has an estimated 5,000 to 7,000 combatants in both countries.